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The pharmacokinetics of paclitaxel hydrochloride oral solutions were studied on 8 beagle dogs. Blood samples were obtained from the cephalic vein under the dosing state of intravenous infusion and were treated by a combined liquid-liquid extraction and the sensitive validated high performance liquid chromatography. The mean oral blood concentration-time curve of paclitaxel in solution form showed a 1-compartment open model. The mean absorption time of the solution was 0.36 h. t1/2 was 7.28 h. The peak concentration (Cmax) was 6.79 μg · dL(-1), the time to the peak concentration (tmax) was 1.63 h, the area under the blood concentration-time curve (AUC0-24) was 67.30 μg · L(-1) · h, the AUC0- ∞ was 71.00 μg · L(-1) · h, the half-body clearance (Cl) was 0.46 h(-1) and the apparent volume of distribution was 1.59 L · kg(-1). It proved that oral solution of paclitaxel hydrochloride was quickly absorbed and had good distribution after drug absorption, and that the oral solution of paclitaxel hydrochloride was an effective means of administration for paclitaxel.At least 30-odd candidates lined up for the Jharkhand assembly elections
When the Election Commission of India’s (ECI) panel was scheduled to oversee the bypolls in Jharkhand, the three parties that had won on margins of over 2,000 votes were exempt from this scrutiny.
At least 30-odd candidates lined up for the Jharkhand assembly elections on Monday. The state is being held after the Bharatiya Janata Party (BJP) lost its majority in the last assembly elections.
For the last three days, the candidates have submitted more than 5,000 affidavits to the ECI.
Those contesting the elections are aware of the ordeal they face. Most want an out-