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Bryce’s i3D Gallery. Yang Tian (杨天) – 21 October .Background
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Although prostatic cancer is initially androgen-dependent, it can become androgen-independent during the course of the disease. Androgen-independence results in a poor prognosis and portends a less successful treatment response to cytotoxic chemotherapy. In this situation, taxol, docetaxel, vinblastine, and irinotecan are often used to treat the patient. The three drugs studied are microtubule inhibitors that have been shown to have activity in androgen-independent tumors. It is not known whether any single agent or combination of agents offers a better prognosis.
Objective
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To determine whether the optimum management of androgen-independent prostate cancer should include use of taxol, docetaxel, vinblastine, or irinotecan.
Methods
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A review of the Medical Oncology Literature. There were 33 references found. Only one clinical trial was selected for the review. Ten of the articles reviewed did not meet the criteria. The remaining 23 articles were reviewed. The studies were divided into two groups. Group 1: Time-response studies and Group 2: Randomized clinical trials.
Results
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The final review included two time-response studies and a randomized clinical trial. Two time-response studies demonstrated that tumor response does correlate with overall survival. The best response in the two time-response studies was a 30% reduction in size. In the randomized clinical trial (S9733), patients with CRFS were treated with a combination of vinblastine, docetaxel, and procarbazine (VDP). A significant improvement was found in PFS and OS.
Conclusion
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At this time, there is insufficient data to recommend the specific administration of taxol, docetaxel, vinblastine, or irinotecan.
United States General Services Administration
The United States General Services Administration (GSA) is the federal government’s centralized procurement office. GSA supports more than
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